Mixed-integer nonlinear optimisation approach to coarse-graining biochemical networks
نویسندگان
چکیده
منابع مشابه
Adiabatic coarse-graining and simulations of stochastic biochemical networks.
We propose a universal approach for analysis and fast simulations of stiff stochastic biochemical networks, which rests on elimination of fast chemical species without a loss of information about mesoscopic, non-Poissonian fluctuations of the slow ones. Our approach is similar to the Born-Oppenheimer approximation in quantum mechanics and follows from the stochastic path integral representation...
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ژورنال
عنوان ژورنال: IET Systems Biology
سال: 2009
ISSN: 1751-8849,1751-8857
DOI: 10.1049/iet-syb:20080098